A SIMULATION-OPTIMIZATION APPROACH TO DETERMINE OPTIMUM FEATURES OF DETENTION ROCKFILL DAMS UNDER FLOOD CONDITION

A simulation-optimization approach to determine optimum features of detention rockfill dams under flood condition

Detention rockfill dams are one of the structural methods that can control flood risks with no impermeable core or membrane.These dams decrease the maximum discharge of flood hydrograph and postpone the time of its occurrence reducing life and financial losses in downstream.In this research study, maybe for the first time, a new methodology based o

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Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis.To date, all inhibitors of cholesterol transport block steps in Generator Assembly lysosomes, limiting our understanding of post-lysosomal transport steps

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Anti-Photoaging Effect of Plant Extract Fermented with Lactobacillus buchneri on CCD-986sk Fibroblasts and HaCaT Keratinocytes

Ultraviolet (UV) exposure triggers the abnormal production of reactive oxygen (ROS) species and the expression of matrix metalloproteinases (MMPs) that are responsible for photoaging.Probiotics are widely used in healthcare and for immune enhancement.One probiotic, Lactobacillus buchneri is found in Kimchi.This study was aimed at assessing the anti

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